Acute cholangitis
Treat sepsis immediately and decompress the obstructed biliary system.
ERCP is particularly useful when stones or sludge involve the common bile duct or major central ducts. It allows sphincterotomy, stone extraction and temporary stenting.
Percutaneous transhepatic access is useful for peripheral intrahepatic stones and strictures that are inaccessible endoscopically.
Antibiotic treatment can begin with:
Piperacillin tazobactam 4.5 g IV every 8 hours by extended infusion, adjusted for renal function.
Definitive treatment
The aim is not merely to treat each infection. Remove stones and correct the anatomical source of recurrent bile stasis.
For disease limited mainly to accessible central ducts, repeated endoscopic or percutaneous clearance may provide satisfactory control.
Anatomical hepatectomy is particularly appropriate for:
- Unilateral disease
- Segmental or lobar hepatic atrophy
- Severe intrahepatic stricturing
- Recurrent liver abscess
- Large persistent stone burden
- Suspected or proven cholangiocarcinoma.
Resecting the affected liver removes both stones and the strictured ducts responsible for recurrent disease.
Bilateral diffuse hepatolithiasis is more difficult and often requires combined endoscopic, percutaneous and operative clearance.
Recurrent cholangitis after apparently successful treatment should trigger repeat imaging for residual stones, recurrent stricture or developing cholangiocarcinoma.