Clinical tool
eGFR
Estimated glomerular filtration rate (CKD-EPI 2021) for staging kidney function.
Calculation details
eGFR = 142 × min(SCr/k, 1)α × max(SCr/k, 1)−1.200 × 0.9938age × sex factor
SCr in mg/dL (µmol/L ÷ 88.4). Female: k = 0.7, α = −0.241, sex factor 1.012. Male: k = 0.9, α = −0.302, sex factor 1. No race coefficient.
G categories (mL/min/1.73 m²)
- G1≥ 90Normal or high
- G260 to 89Mildly decreased
- G3a45 to 59Mildly to moderately decreased
- G3b30 to 44Moderately to severely decreased
- G415 to 29Severely decreased
- G5< 15Kidney failure
CKD requires persistent kidney abnormality for at least 3 months. G1 and G2 require additional evidence of kidney disease.
eGFR is primarily used for assessment and staging of chronic kidney disease. Cockcroft-Gault creatinine clearance may still be required for medication dosing when the drug reference specifically uses CrCl. The two are not interchangeable: Creatinine Clearance.
Limitations
Creatinine-based eGFR may be less reliable in:
- Acute kidney injury, or rapidly changing renal function
- Very low or very high muscle mass, including amputation and severe cachexia
- Bodybuilders or unusually high muscle mass
- Pregnancy
- Patients receiving dialysis
- Any situation where creatinine generation is substantially abnormal
For practising medics only. Clinical tools support judgement, they do not replace it. Always verify results against current guidelines and the patient in front of you.