Anal Cancer
Anal cancer includes malignancies arising from the anal canal and perianal skin.
Squamous cell carcinoma is by far the commonest histology. Less common tumours include adenocarcinoma and melanoma, which follow different oncological pathways.
Human papillomavirus infection, particularly HPV 16, plays a major role in anal squamous carcinogenesis.
Treatment must therefore begin with histological confirmation rather than treating all anal malignancies as one disease.

