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Anal Cancer

Anal cancer includes malignancies arising from the anal canal and perianal skin.

Squamous cell carcinoma is by far the commonest histology. Less common tumours include adenocarcinoma and melanoma, which follow different oncological pathways.

Human papillomavirus infection, particularly HPV 16, plays a major role in anal squamous carcinogenesis.

Treatment must therefore begin with histological confirmation rather than treating all anal malignancies as one disease.

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Diverticular Disease

Colonic diverticula are acquired mucosal and submucosal herniations through points of weakness where vasa recta penetrate the muscular wall. Disease is predominantly sigmoid in Western populations, although right sided disease is more prevalent in some populations.

Diverticulosis refers to the anatomical presence of diverticula.

Diverticular disease implies clinically significant symptoms or complications.

Complications include acute diverticulitis, abscess, fistula, stricture, obstruction, bleeding and perforation.