Supportive: fluids (1.5 to 2 L daily unless restricted), fibre 25 to 30 g daily, physical activity, toilet routine 20 to 30 minutes after meals with feet raised on a stool, review constipating drugs, privacy and assistance with toileting.
Pharmacological
- Disimpaction in adults: macrogol (polyethylene glycol with electrolytes) 8 sachets dissolved in 1 L water drunk over 6 hours, daily for up to 3 days; or bisacodyl 10 mg suppository daily with glycerol 4 g suppositories; or sodium citrate micro-enema 5 mL; or arachis oil enema 130 mL retained overnight for hard stool, followed the next morning by a glycerol or bisacodyl suppository.
- Avoid sodium phosphate enemas in renal impairment, children under 2 years and frail older adults.
- Children (1 to 12 years): macrogol 3350 1 to 1.5 g/kg daily for 3 days (maximum 100 g daily), then 0.4 to 0.8 g/kg daily maintenance.
- Maintenance: macrogol 1 to 3 sachets daily, or lactulose 15 to 30 mL twice daily, plus senna 15 mg at night or bisacodyl 5 to 10 mg at night; continue for several months.
- Opioid induced: add methylnaltrexone 12 mg SC on alternate days or naloxegol 25 mg daily.
Procedures: manual disimpaction under sedation or anaesthesia when enemas fail; surgery for perforation or ischaemia.
Special groups: neurological patients (scheduled bowel programme with suppositories and digital stimulation), children (behavioural programme and toilet training), palliative care (prophylactic laxatives with every opioid).
Red flags: abdominal distension with vomiting, peritonism, rectal bleeding, fever, new neurological signs (cauda equina), failure of disimpaction.
Follow-up: review at 1 to 2 weeks, ensure daily soft stool; taper laxatives slowly only after 1 to 3 months of normal bowel habit.